Quorumetrix
Data Driven Design
Quantitative Motion Design
Science in Motion: Elevate Your Research with Stunning Graphics and Engaging Animations
Featured Videos
Connectomic reconstruction and synaptic architecture of the Drosophila Ventral Nerve Cord
The Nerve cord is the flies version of a spinal cord. This video explores the intricacies of the wiring of the limbs and wing motor neurons, as well as the other classes of neurons in the nerve cord.
Cortical Density
A voyage through time in neuroscience:
This animation reveals the immense scientific progress that has been made in visualizing the brain. The Golgi method, established around the year 1873, stains ~1-5% of neurons, leading to a view of neurons surrounded by much empty space. Modern methods detail the true complexity and density of brain tissue.
Winner: BRAIN at 10 celebrating 10 years of BRAIN-funded research.
Quorumetrix Studio:
2023 in review [Film Reel]
2023 has been a fulfilling year at Quorumetrix Studio, a mix of long-term projects seeing the light of day, and new projects that pushed me to experiment and grow. Thanks to all my brilliant collaborators and clients who have become friends over the years.
3D reconstruction of the fly brain connectome.
Over 139,000 neurons connections mapped
Since 2019, scientists and experienced proofreaders have utilized FlyWire to proofread AI segmentation of a full fly brain (Dorkenwald et al., Zheng et al.). As of July 2023, the FlyWire flagship preprint Neuronal wiring diagram of an adult brain is available on bioRxiv, which includes 127,978 proofread neurons (Dorkenwald et al.). The companion annotation paper includes over 700,000 labels (Schlegel et al.).
Learn more at: https://flywire.ai/
Video featured at SfN 2023
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A cubic millimeter of mouse brain
An intuition pump to help us appreciate the intricate interconnectivity of cells in your brain
An exploration of the cell types, forming different layers of the cortex. Audio is generated by sonification of optical physiology data of neural activity.
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Data from the MICrONS project: www.microns-explorer.org/cortical-mm3
Featured by the Allen Institute for Brain Science
A Simian Symphony
Sharp Wave Ripples in the primate hippocampus
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In this video, we explore a compressed pattern of brain activity seen in all mammals, that is thought to underlie the creation and consolidation of memories. The Sharp Wave Ripples (SWRs) in the hippocampus are the largest oscillation in the brain, involving 10’s of thousands of neurons.
This video is the result of a fascinating collaboration between Quorumetrix Studio with Kari Hoffman's Perception Plasticity & Learning Lab and Diagnostic Biochips, Inc
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Fibers of the heart
Discovery of a new fiber system in the heart of mammals
Cardiomyocyte orientation recovery at micrometer scale reveals long-axis fiber continuum in heart walls
Drisya Dileep, Tabish A Syed, Tyler FW Sloan,
Perundurai S Dhandapany, Kaleem Siddiqi
Minhajuddin Sirajuddin
The EMBO Journal (2023)
DOI: /10.15252/embj.2022113288
Animating Astrocytes
Organizing Principles of Astrocytic Nanoarchitecture in the Mouse Cerebral Cortex.
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Christopher K. Salmon, Tabish A. Syed, J. Benjamin Kacerovsky, Nensi Alivodej, Alexandra L. Schober, Tyler F.W. Sloan, Michael T. Pratte, Michael P. Rosen, Miranda Green, Adario Chirgwin-Dasgupta, Shaurya Mehta, Affan Jilani, Yanan Wang, Hojatollah Vali, Craig A. Mandato, Kaleem Siddiqi, Keith K. Murai
Current Biology 2023
DOI: doi.org/10.1016/j.cub.2023.01.043
What is it like to be a dendrite?
My last visualization of #MICrONS layer2/3, to show the density of synapses and neuronal processes from a dendrites point of view.
Details:
Each orange cube represents one of 3.2 m synapses. Purple cubes = post-synapses of the neuron we enter. Neuronal activity from calcium imaging: Initial zoom firing rate ~32x. Remaining activity shown ~1.6x real-time. The animation is a drop in the ocean next to the epic concerted effort by the teams who did the hard science and made it open.
Thanks to the #MICrONS team for making brains accessible: microns-explorer.org
Connections in the Brain
A compilation of videos made using the MICrONS dataset: a collection of electrophysiological recordings, optogenetic experiments, and anatomical data from mouse neocortical circuits produced by the Allen Institute for Brain Science.
It was collected to provide a comprehensive and integrated understanding of the structure and function of cortical circuits, with the ultimate goal of developing better treatments for neurological and psychiatric disorders.
Cerebellar Circuitry
Explore the mysteries of the cerebellum, the brain's 'little brain', and its beautiful Purkinje cells in this captivating video featured in a recent Harvard Medical School news article.
Primary research article:
Structured cerebellar connectivity supports resilient pattern separation:
guyen, T.M., Thomas, L.A., et al. Nature (2022).
doi: 10.1038/s41586-022-05471-w